continue_lwf.py

import torch
from torch import nn
import torch.nn.functional as F
import numpy as np
import matplotlib.pyplot as plt
from tqdm import tqdm
import os
import argparse
import time

import warnings
warnings.filterwarnings("ignore")

import torch.distributed as dist
from torch.nn.parallel import DistributedDataParallel
from tensorboardX import SummaryWriter

from monai.losses import DiceCELoss
from monai.inferers import sliding_window_inference
from monai.data import load_decathlon_datalist, decollate_batch, DistributedSampler
from monai.transforms import AsDiscrete
from monai.metrics import DiceMetric

from model.swinunetr import SwinUNETR
from model.swinunetr_partial_onehot import SwinUNETR as SwinUNETR_onehot
from model.swinunetr_partial_v3 import SwinUNETR as SwinUNETR_partial_v3
from dataset.dataloader_continue import get_loader
from utils import loss
from optimizers.lr_scheduler import LinearWarmupCosineAnnealingLR


torch.multiprocessing.set_sharing_strategy('file_system')


class DiceLoss(nn.Module):
    def __init__(self, weight=None, ignore_index=None, num_classes=3, **kwargs):
        super(DiceLoss, self).__init__()
        self.kwargs = kwargs
        self.weight = weight
        self.ignore_index = ignore_index
        self.num_classes = num_classes
        self.dice = loss.BinaryDiceLoss(**self.kwargs)

    def forward(self, predict, target, organ_list):
        total_loss = []
        predict = F.sigmoid(predict)

        total_loss = []
        B = predict.shape[0]

        for b in range(B):
            for organ in organ_list:
                dice_loss = self.dice(predict[b, organ-1], target[b, organ-1])
                total_loss.append(dice_loss)
            
        total_loss = torch.stack(total_loss)

        return total_loss.sum()/total_loss.shape[0]


class Multi_BCELoss(nn.Module):
    def __init__(self, ignore_index=None, num_classes=3, **kwargs):
        super(Multi_BCELoss, self).__init__()
        self.kwargs = kwargs
        self.num_classes = num_classes
        self.ignore_index = ignore_index
        self.criterion = nn.BCEWithLogitsLoss()

    def forward(self, predict, target, organ_list):
        assert predict.shape[2:] == target.shape[2:], 'predict & target shape do not match'
        total_loss = []
        B = predict.shape[0]

        for b in range(B):
            for organ in organ_list:
                ce_loss = self.criterion(predict[b, organ-1], target[b, organ-1])
                total_loss.append(ce_loss)
        total_loss = torch.stack(total_loss)

        return total_loss.sum()/total_loss.shape[0]


def train(args, train_loader, model, optimizer, loss_func_dice, loss_func_bce, loss_func_ce):
    model.train()
    loss_bce_ave = 0
    loss_ce_ave = 0
    loss_dice_ave = 0
    epoch_iterator = tqdm(
        train_loader, desc="Training (X / X Steps) (loss=X.X)", dynamic_ncols=True
    )
    for step, batch in enumerate(epoch_iterator):
        x, y, name = batch["image"].to(args.device), batch["post_label"].float().to(args.device), batch['name']
        logit_map = model(x)[-1]
        
        if args.out_nonlinear == 'sigmoid':
            print(torch.nonzero(y[:, :, 48, 48, 48] == 1)[:, 1] + 1)
            term_seg_Dice = loss_func_dice.forward(logit_map, y, args.organ_list)
            term_seg_BCE = loss_func_bce.forward(logit_map, y, args.organ_list)
            old_dice = loss_func_dice(logit_map, y, args.old_organ_list)
            old_bce = loss_func_bce(logit_map, y, args.old_organ_list)
            loss = term_seg_BCE + term_seg_Dice + old_dice + old_bce
            loss_bce_ave += term_seg_BCE.item() + old_bce.item()
            loss_dice_ave += term_seg_Dice.item() + old_dice.item()
            epoch_iterator.set_description(
                "Epoch=%d: Training (%d / %d Steps) (dice_loss=%2.5f, bce_loss=%2.5f)" % (
                    args.epoch, step, len(train_loader), term_seg_Dice.item(), term_seg_BCE.item())
            )
        elif args.out_nonlinear == 'softmax':
            b, c, d, h, w = y.shape
            label = y.new_zeros((b, d, h, w), dtype=torch.long)
            for icls in args.organ_list + args.old_organ_list:
                label[y[:, icls-1] == 1] = icls
            # old_label = y.new_zeros((b, d, h, w), dtype=torch.long)
            # for icls in args.old_organ_list:
                # old_label[y[:, icls-1] == 1] = icls
            
            print(label[:, 48, 48, 48])
            term_seg_Dice = loss_func_dice.forward(logit_map[:, 1:], y, args.organ_list)
            term_seg_CE = loss_func_ce(logit_map, label)
            old_dice = loss_func_dice(logit_map[:, 1:], y, args.old_organ_list)
            # old_ce = loss_func_ce(logit_map, old_label)
            loss = term_seg_Dice + term_seg_CE + old_dice
            loss_ce_ave += term_seg_CE.item()
            loss_dice_ave += term_seg_Dice.item()
            epoch_iterator.set_description(
                "Epoch=%d: Training (%d / %d Steps) (dice_loss=%2.5f, ce_loss=%2.5f)" % (
                    args.epoch, step, len(train_loader), term_seg_Dice.item(), term_seg_CE.item())
            )
        
        loss.backward()
        optimizer.step()
        optimizer.zero_grad()
        torch.cuda.empty_cache()
    
    if args.out_nonlinear == 'sigmoid':
        print('Epoch=%d: ave_dice_loss=%2.5f, ave_bce_loss=%2.5f' % (args.epoch, loss_dice_ave/len(epoch_iterator), loss_bce_ave/len(epoch_iterator)))
    elif args.out_nonlinear == 'softmax':
        print('Epoch=%d: ave_dice_loss=%2.5f, ave_ce_loss=%2.5f' % (args.epoch, loss_dice_ave/len(epoch_iterator), loss_ce_ave/len(epoch_iterator)))

    return loss_dice_ave / len(epoch_iterator), loss_bce_ave / len(epoch_iterator), loss_ce_ave / len(epoch_iterator)


def process(args):
    rank = 0

    if args.dist:
        dist.init_process_group(backend="nccl", init_method="env://")
        rank = args.local_rank
    args.device = torch.device(f"cuda:{rank}")
    torch.cuda.set_device(args.device)

    # prepare the 3D model
    if args.model == 'swinunetr_partial':
        model = SwinUNETR_partial_v3(
            img_size=(args.roi_x, args.roi_y, args.roi_z),
            in_channels=1,
            out_channels=args.out_channels,
            feature_size=48,
            drop_rate=0.0,
            attn_drop_rate=0.0,
            dropout_path_rate=0.0,
            use_checkpoint=False,
            encoding=args.trans_encoding,
        )
    elif args.model == 'swinunetr':
        model = SwinUNETR(
            img_size=(args.roi_x, args.roi_y, args.roi_z),
            in_channels=1,
            out_channels=args.out_channels,
            feature_size=48,
            drop_rate=0.0,
            attn_drop_rate=0.0,
            dropout_path_rate=0.0,
            use_checkpoint=False,
        )
    elif args.model == 'our_onehot':
        model = SwinUNETR_onehot(
            img_size=(args.roi_x, args.roi_y, args.roi_z),
            in_channels=1,
            out_channels=args.out_channels,
            feature_size=48,
            drop_rate=0.0,
            attn_drop_rate=0.0,
            dropout_path_rate=0.0,
            use_checkpoint=False,
            encoding=args.trans_encoding,
        )
    
    #Load pre-trained weights
    store_dict = model.state_dict()
    pretrain_checkpoint = torch.load(args.pretrain)
    if 'state_dict' in pretrain_checkpoint:
        model_dict = pretrain_checkpoint["state_dict"]
    else:
        model_dict = pretrain_checkpoint['net']
    torch.nn.modules.utils.consume_prefix_in_state_dict_if_present(
        model_dict, "module."
    )
    
    for key in model_dict.keys():
        # if 'out' not in key:
        #     store_dict[key] = model_dict[key]
        # else:
        #     print(f'{key} is not in model state dict')
        store_dict[key] = model_dict[key]

    model.load_state_dict(store_dict)
    print('Use pretrained weights')

    if args.model == 'swinunetr_partial' and args.trans_encoding == 'word_embedding':
        word_embedding = torch.load(args.word_embedding)
        model.organ_embedding.data = word_embedding.float()
        print('load word embedding')

    model.to(args.device)
    model.train()
    if args.dist:
        model = DistributedDataParallel(model, device_ids=[args.device])

    # criterion and optimizer
    # loss_function = DiceCELoss(to_onehot_y=True, softmax=True)
    loss_func_dice = DiceLoss().to(args.device)
    loss_func_bce = Multi_BCELoss().to(args.device)
    weight = torch.ones(args.out_channels).cuda()
    # weight[27] = 100
    loss_func_ce = nn.CrossEntropyLoss(weight)

    if args.model in ['swinunetr_partial', 'our_onehot'] :
        optimizer = torch.optim.AdamW(model.parameters(), lr=args.lr, weight_decay=args.weight_decay)
    elif args.model == 'swinunetr':
        model_params = [v for k, v in model.named_parameters() if 'out' not in k]
        class_params = model.out.parameters()
        optimizer = torch.optim.AdamW(
            [{'params': class_params, 'lr': args.lr},
            {'params': model_params}],
            lr=args.lr, weight_decay=args.weight_decay)

    scheduler = LinearWarmupCosineAnnealingLR(optimizer, warmup_epochs=args.warmup_epoch, max_epochs=args.max_epoch)

    if args.resume:
        checkpoint = torch.load(args.resume)
        if args.dist:
            model.load_state_dict(checkpoint['net'])
        else:
            store_dict = model.state_dict()
            model_dict = checkpoint['net']
            for key in model_dict.keys():
                store_dict['.'.join(key.split('.')[1:])] = model_dict[key]
            model.load_state_dict(store_dict)
        
        optimizer.load_state_dict(checkpoint['optimizer'])
        args.epoch = checkpoint['epoch']
        scheduler.load_state_dict(checkpoint['scheduler'])
        
        print('success resume from ', args.resume)

    torch.backends.cudnn.benchmark = True
    
    train_loader, train_sampler = get_loader(args)

    if rank == 0:
        writer = SummaryWriter(log_dir=os.path.join(args.log_dir, args.log_name))
        print('Writing Tensorboard logs to ', os.path.join(args.log_dir, args.log_name))
    
    if not os.path.isdir(os.path.join(args.log_dir, args.log_name)):
        os.mkdir(os.path.join(args.log_dir, args.log_name))

    while args.epoch < args.max_epoch:
        if args.dist:
            dist.barrier()
            train_sampler.set_epoch(args.epoch)
        scheduler.step()

        loss_dice, loss_bce, loss_ce = train(args, train_loader, model, optimizer, loss_func_dice, loss_func_bce, loss_func_ce)
        if rank == 0:
            writer.add_scalar('train_dice_loss', loss_dice, args.epoch)
            writer.add_scalar('train_bce_loss', loss_bce, args.epoch)
            writer.add_scalar('train_ce_loss', loss_ce, args.epoch)
            # writer.add_scalar('lr', scheduler.get_lr(), args.epoch)

        if (args.epoch % args.store_num == 0 and args.epoch != 0) and rank == 0:
            checkpoint = {
                "net": model.state_dict(),
                'optimizer':optimizer.state_dict(),
                'scheduler': scheduler.state_dict(),
                "epoch": args.epoch
            }
            torch.save(checkpoint, os.path.join(args.log_dir, args.log_name, f'epoch_{args.epoch}.pth'))
            print('save model success')

        args.epoch += 1

    if args.dist:
        dist.destroy_process_group()

def main():
    parser = argparse.ArgumentParser()
    ## for distributed training
    parser.add_argument('--dist', default=False, action='store_true', help='distributed training or not')
    parser.add_argument("--local_rank", type=int)
    parser.add_argument("--device")
    parser.add_argument("--epoch", default=0)
    ## logging
    parser.add_argument('--log_dir', default='output', help='Log directory.')
    parser.add_argument('--log_name', type=str, required=True, help='Experiment name under the log dir.')
    ## model load
    parser.add_argument('--model', type=str, choices=['swinunetr', 'swinunetr_partial', 'our_onehot'])
    parser.add_argument('--resume', default=None, help='The path resume from checkpoint')
    parser.add_argument('--pretrain', default='./pretrained_weights/swin_unetr.base_5000ep_f48_lr2e-4_pretrained.pt', 
                        help='The path of pretrain model')
    parser.add_argument('--trans_encoding', default='word_embedding', 
                        help='the type of encoding: rand_embedding or word_embedding')
    parser.add_argument('--word_embedding', default='./pretrained_weights/txt_encoding.pth', 
                        help='The path of word embedding')
    parser.add_argument('--out_nonlinear', type=str, choices=['softmax', 'sigmoid'])
    parser.add_argument('--out_channels', type=int)
    ## hyperparameter
    parser.add_argument('--max_epoch', default=2000, type=int, help='Number of training epoches')
    parser.add_argument('--store_num', default=10, type=int, help='Store model how often')
    parser.add_argument('--warmup_epoch', default=100, type=int, help='number of warmup epochs')
    parser.add_argument('--lr', default=1e-4, type=float, help='Learning rate')
    parser.add_argument('--weight_decay', default=1e-5, help='Weight Decay')
    ## dataset
    parser.add_argument('--dataset_list', nargs='+', default=['PAOT_123457891213', 'PAOT_10_inner']) # 'PAOT', 'felix'
    ### please check this argment carefully
    ### PAOT: include PAOT_123457891213 and PAOT_10
    ### PAOT_123457891213: include 1 2 3 4 5 7 8 9 12 13
    ### PAOT_10_inner: same with NVIDIA for comparison
    ### PAOT_10: original division
    ### for cross_validation 'cross_validation/PAOT_0' 1 2 3 4
    parser.add_argument('--data_root_path', default='', help='data root path')
    parser.add_argument('--data_txt_path', default='./dataset/dataset_list/', help='data txt path')
    parser.add_argument('--train_data_txt_path', type=str, help='train data txt path.')
    parser.add_argument('--val_data_txt_path', type=str, help='val data txt path.')
    parser.add_argument('--test_data_txt_path', type=str, help='test data txt path.')
    parser.add_argument('--continue_data_txt_path', type=str, help='continue data txt path.')
    parser.add_argument('--batch_size', default=1, type=int, help='batch size')
    parser.add_argument('--num_workers', default=8, type=int, help='workers numebr for DataLoader')
    parser.add_argument('--a_min', default=-175, type=float, help='a_min in ScaleIntensityRanged')
    parser.add_argument('--a_max', default=250, type=float, help='a_max in ScaleIntensityRanged')
    parser.add_argument('--b_min', default=0.0, type=float, help='b_min in ScaleIntensityRanged')
    parser.add_argument('--b_max', default=1.0, type=float, help='b_max in ScaleIntensityRanged')
    parser.add_argument('--space_x', default=1.5, type=float, help='spacing in x direction')
    parser.add_argument('--space_y', default=1.5, type=float, help='spacing in y direction')
    parser.add_argument('--space_z', default=1.5, type=float, help='spacing in z direction')
    parser.add_argument('--roi_x', default=96, type=int, help='roi size in x direction')
    parser.add_argument('--roi_y', default=96, type=int, help='roi size in y direction')
    parser.add_argument('--roi_z', default=96, type=int, help='roi size in z direction')
    parser.add_argument('--num_samples', default=2, type=int, help='sample number in each ct')

    parser.add_argument('--phase', default='train', help='train or validation or test')
    parser.add_argument('--uniform_sample', action="store_true", default=False, help='whether utilize uniform sample strategy')
    parser.add_argument('--datasetkey', nargs='+', default=['01', '02', '03', '04', '05', 
                                            '07', '08', '09', '12', '13', '10_03', 
                                            '10_06', '10_07', '10_08', '10_09', '10_10'],
                                            help='the content for ')
    parser.add_argument('--cache_dataset', action="store_true", default=False, help='whether use cache dataset')
    parser.add_argument('--cache_rate', default=0.005, type=float, help='The percentage of cached data in total')

    parser.add_argument('--organ_list', nargs='+', type=int, required=True, help='Target training organ ids.')
    parser.add_argument('--old_organ_list', nargs='+', type=int, required=True)
    
    args = parser.parse_args()
    
    process(args=args)

if __name__ == "__main__":
    main()