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Poly2 top reporting #93

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kpaulfriedman opened this issue Apr 10, 2024 · 2 comments
Open

Poly2 top reporting #93

kpaulfriedman opened this issue Apr 10, 2024 · 2 comments
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@kpaulfriedman
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Poly2 parabolic responses that look like an inverted U shape capture the model top as the top of the data points and not the top of the model curve. Is this intentional? I can’t remember from our discussions on the new poly2.
Here’s an example.

tcplConf(user=', pass='', db='invitrodb', drvr='MySQL', host='ccte-mysql-res.epa.gov')
tcplPlot(output='console',fld='m4id', val=7896464)

You can see other models would have similar tops to what is actually given, but the poly2 has this “tail” up that doesn’t get captured by the top. It’s not bad to just have the top be the top of the responses – but I wondered overall for tcpl what makes sense here to be consistent with how we fit and call the theoretical top.

@kpaulfriedman kpaulfriedman added the question Further information is requested label Apr 10, 2024
@madison-feshuk madison-feshuk transferred this issue from USEPA/CompTox-ToxCast-tcpl Jul 10, 2024
@Kelly-Carstens-EPA
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Kelly-Carstens-EPA commented Jul 22, 2024

Adding to poly2 investigations, I noticed a trend where poly2 did not fit to the lowest concentrations when the concentrations were near the same effect size as the highest concentration tested. The same fitting occurred in both directions (flipped the data by multiplying by -1). In these 2 example plots, bmed = 0.

image
image

@madison-feshuk
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From 9/25 discussion, Poly2 top should be at modeled response at concentration with max(median(response)). Currently top is model predicted response at max(conc).

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