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NC_012920.1.gb
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NC_012920.1.gb
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LOCUS NC_012920 16569 bp DNA circular PRI 31-OCT-2014
DEFINITION Homo sapiens mitochondrion, complete genome.
ACCESSION NC_012920 AC_000021
VERSION NC_012920.1
DBLINK BioProject: PRJNA30353
KEYWORDS RefSeq.
SOURCE mitochondrion Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 16569)
AUTHORS Andrews,R.M., Kubacka,I., Chinnery,P.F., Lightowlers,R.N.,
Turnbull,D.M. and Howell,N.
TITLE Reanalysis and revision of the Cambridge reference sequence for
human mitochondrial DNA
JOURNAL Nat. Genet. 23 (2), 147 (1999)
PUBMED 10508508
REFERENCE 2 (bases 324 to 743)
AUTHORS Andrews,R.M., Kubacka,I., Chinnery,P.F., Lightowlers,R.N.,
Turnbull,D.M. and Howell,N.
TITLE Reanalysis and revision of the Cambridge reference sequence for
human mitochondrial DNA
JOURNAL Nat. Genet. 23 (2), 147 (1999)
PUBMED 10508508
REFERENCE 3 (bases 1 to 16569)
AUTHORS Anderson,S., Bankier,A.T., Barrell,B.G., de Bruijn,M.H.,
Coulson,A.R., Drouin,J., Eperon,I.C., Nierlich,D.P., Roe,B.A.,
Sanger,F., Schreier,P.H., Smith,A.J., Staden,R. and Young,I.G.
TITLE Sequence and organization of the human mitochondrial genome
JOURNAL Nature 290 (5806), 457-465 (1981)
PUBMED 7219534
REFERENCE 4 (bases 15888 to 15954)
AUTHORS Anderson,S., Bankier,A.T., Barrell,B.G., de Bruijn,M.H.,
Coulson,A.R., Drouin,J., Eperon,I.C., Nierlich,D.P., Roe,B.A.,
Sanger,F., Schreier,P.H., Smith,A.J., Staden,R. and Young,I.G.
TITLE Sequence and organization of the human mitochondrial genome
JOURNAL Nature 290 (5806), 457-465 (1981)
PUBMED 7219534
REFERENCE 5 (bases 1 to 16569)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (08-JUL-2009) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 6 (bases 1 to 16569)
AUTHORS Kogelnik,A.M. and Lott,M.T.
TITLE Direct Submission
JOURNAL Submitted (24-AUG-2006) Mitomap.org, Center for Molecular and
Mitochondrial Medicine and Genetics (MAMMAG) University of
California, University of California, Irvine, Irvine, CA
92697-3940, USA
REMARK Sequence update by submitter
REFERENCE 7 (bases 1 to 16569)
AUTHORS Kogelnik,A.M. and Lott,M.T.
TITLE Direct Submission
JOURNAL Submitted (18-APR-1997) Center for Molecular Medicine, Emory
University School of Medicine, 1462 Clifton Road, Suite 420,
Atlanta, GA 30322, USA
REMARK sequence updated
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from J01415.
On Jul 8, 2009 this sequence version replaced gi:115315570.
This sequence is a corrected version of the HUMMTCG reference
sequence. The original Cambridge reference sequence (CRS) is
preserved as GenBank J01415 gi:337188 [PMID:7219534]. Corrections
have been made and annotated per the re-sequencing of the original
material by Andrews et al [PMID:10508508].
This Revised Cambridge Reference Sequence (rCRS) has eighteen
specific corrections or confirmations of the original 1981 sequence
of Anderson et al [PMID:7219534]. Seven nucleotides are confirmed
as rare polymorphisms, maintained as: 263A, 311C-315C, 750A, 1438A,
4769A, 8860A, and 15326A. Eleven nucleotides are error
corrections: 3107del, 3423T, 4985A, 9559C, 11335C, 13702C, 14199T,
14272C, 14365C, 14368C, and 14766C. These 11 errors in the
original Cambridge sequence were determined to be either outright
sequencing errors (8 instances) or due to the presence of bovine
DNA (2 instances) or HeLa DNA (1 instance) mixed in with the
original human placental DNA [PMID:10508508]. HISTORICAL
NUCLEOTIDE NUMBERS ARE MAINTAINED by indicating 3107del as 'N'.
A summary table of the reanalysis data is available online at
http://www.mitomap.org/MITOMAP/CambridgeReanalysis
L-strand is shown.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..16569
/organism="Homo sapiens"
/organelle="mitochondrion"
/mol_type="genomic DNA"
/isolation_source="caucasian"
/db_xref="taxon:9606"
/tissue_type="placenta"
/country="United Kingdom: Great Britain"
/note="this is the rCRS"
D-loop complement(join(16024..16569,1..576))
gene 577..647
/gene="TRNF"
/nomenclature="Official Symbol: MT-TF | Name:
mitochondrially encoded tRNA phenylalanine | Provided by:
HGNC:HGNC:7481"
/db_xref="GeneID:4558"
/db_xref="HGNC:HGNC:7481"
/db_xref="MIM:590070"
tRNA 577..647
/gene="TRNF"
/product="tRNA-Phe"
/note="NAR: 1455"
/anticodon=(pos:611..613,aa:Phe,seq:gaa)
/codon_recognized="UUC"
/db_xref="GeneID:4558"
/db_xref="HGNC:HGNC:7481"
/db_xref="MIM:590070"
gene 648..1601
/gene="RNR1"
/gene_synonym="MTRNR1"
/nomenclature="Official Symbol: MT-RNR1 | Name:
mitochondrially encoded 12S RNA | Provided by:
HGNC:HGNC:7470"
/db_xref="GeneID:4549"
/db_xref="HGNC:HGNC:7470"
/db_xref="MIM:561000"
rRNA 648..1601
/gene="RNR1"
/gene_synonym="MTRNR1"
/product="s-rRNA"
/note="12S rRNA; 12S ribosomal RNA"
/db_xref="GeneID:4549"
/db_xref="HGNC:HGNC:7470"
/db_xref="MIM:561000"
STS 1478..2187
/standard_name="PMC316374P5"
/db_xref="UniSTS:272966"
gene 1602..1670
/gene="TRNV"
/gene_synonym="MTTV"
/nomenclature="Official Symbol: MT-TV | Name:
mitochondrially encoded tRNA valine | Provided by:
HGNC:HGNC:7500"
/db_xref="GeneID:4577"
/db_xref="HGNC:HGNC:7500"
/db_xref="MIM:590105"
tRNA 1602..1670
/gene="TRNV"
/gene_synonym="MTTV"
/product="tRNA-Val"
/note="NAR: 2053"
/anticodon=(pos:1633..1635,aa:Val,seq:tac)
/codon_recognized="GUA"
/db_xref="GeneID:4577"
/db_xref="HGNC:HGNC:7500"
/db_xref="MIM:590105"
gene 1671..3229
/gene="RNR2"
/gene_synonym="MTRNR2"
/nomenclature="Official Symbol: MT-RNR2 | Name:
mitochondrially encoded 16S RNA | Provided by:
HGNC:HGNC:7471"
/db_xref="GeneID:4550"
/db_xref="HGNC:HGNC:7471"
/db_xref="MIM:561010"
rRNA 1671..3229
/gene="RNR2"
/gene_synonym="MTRNR2"
/product="l-rRNA"
/note="16S ribosomal RNA; 16S rRNA"
/db_xref="GeneID:4550"
/db_xref="HGNC:HGNC:7471"
/db_xref="MIM:561010"
STS 2062..2203
/gene="RNR2"
/gene_synonym="MTRNR2"
/standard_name="D3S2893E"
/db_xref="UniSTS:150884"
STS 2712..2884
/gene="RNR2"
/gene_synonym="MTRNR2"
/standard_name="NIB250"
/db_xref="UniSTS:56529"
STS 2806..2946
/gene="RNR2"
/gene_synonym="MTRNR2"
/standard_name="PMC31832P1"
/db_xref="UniSTS:273091"
misc_feature 3107
/note="preserves historical genome annotation numbering"
gene 3230..3304
/gene="TRNL1"
/gene_synonym="MTTL1"
/nomenclature="Official Symbol: MT-TL1 | Name:
mitochondrially encoded tRNA leucine 1 (UUA/G) | Provided
by: HGNC:HGNC:7490"
/db_xref="GeneID:4567"
/db_xref="HGNC:HGNC:7490"
/db_xref="MIM:590050"
tRNA 3230..3304
/gene="TRNL1"
/gene_synonym="MTTL1"
/product="tRNA-Leu"
/note="NAR: 1054"
/anticodon=(pos:3265..3267,aa:Leu,seq:taa)
/codon_recognized="UUR"
/db_xref="GeneID:4567"
/db_xref="HGNC:HGNC:7490"
/db_xref="MIM:590050"
gene 3307..4262
/gene="ND1"
/gene_synonym="MTND1"
/nomenclature="Official Symbol: MT-ND1 | Name:
mitochondrially encoded NADH dehydrogenase 1 | Provided
by: HGNC:HGNC:7455"
/db_xref="GeneID:4535"
/db_xref="HGNC:HGNC:7455"
/db_xref="MIM:516000"
CDS 3307..4262
/gene="ND1"
/gene_synonym="MTND1"
/note="NADH dehydrogenase, subunit 1 (complex I); TAA stop
codon is completed by the addition of 3' A residues to the
mRNA"
/codon_start=1
/transl_except=(pos:4261..4262,aa:TERM)
/transl_table=2
/product="NADH dehydrogenase subunit 1"
/protein_id="YP_003024026.1"
/db_xref="GeneID:4535"
/db_xref="HGNC:HGNC:7455"
/db_xref="MIM:516000"
/translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG
LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGL
LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF
NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG
PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTA
YPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT"
STS 3740..3834
/gene="ND1"
/gene_synonym="MTND1"
/standard_name="D17S1473E"
/db_xref="UniSTS:151680"
STS 4189..4813
/standard_name="PMC55343P1"
/db_xref="UniSTS:273322"
gene 4263..4331
/gene="TRNI"
/gene_synonym="MTTI"
/nomenclature="Official Symbol: MT-TI | Name:
mitochondrially encoded tRNA isoleucine | Provided by:
HGNC:HGNC:7488"
/db_xref="GeneID:4565"
/db_xref="HGNC:HGNC:7488"
/db_xref="MIM:590045"
tRNA 4263..4331
/gene="TRNI"
/gene_synonym="MTTI"
/product="tRNA-Ile"
/note="NAR: 0997"
/anticodon=(pos:4292..4294,aa:Ile,seq:gat)
/codon_recognized="AUC"
/db_xref="GeneID:4565"
/db_xref="HGNC:HGNC:7488"
/db_xref="MIM:590045"
gene complement(4329..4400)
/gene="TRNQ"
/gene_synonym="MTTQ"
/nomenclature="Official Symbol: MT-TQ | Name:
mitochondrially encoded tRNA glutamine | Provided by:
HGNC:HGNC:7495"
/db_xref="GeneID:4572"
/db_xref="HGNC:HGNC:7495"
/db_xref="MIM:590030"
tRNA complement(4329..4400)
/gene="TRNQ"
/gene_synonym="MTTQ"
/product="tRNA-Gln"
/note="NAR: 0597"
/anticodon=(pos:complement(4365..4367),aa:Gln,seq:ttg)
/codon_recognized="CAA"
/db_xref="GeneID:4572"
/db_xref="HGNC:HGNC:7495"
/db_xref="MIM:590030"
gene 4402..4469
/gene="TRNM"
/gene_synonym="MTTM"
/nomenclature="Official Symbol: MT-TM | Name:
mitochondrially encoded tRNA methionine | Provided by:
HGNC:HGNC:7492"
/db_xref="GeneID:4569"
/db_xref="HGNC:HGNC:7492"
/db_xref="MIM:590065"
tRNA 4402..4469
/gene="TRNM"
/gene_synonym="MTTM"
/product="tRNA-Met"
/note="NAR: 1297"
/anticodon=(pos:4432..4434,aa:Met,seq:cat)
/codon_recognized="AUG"
/db_xref="GeneID:4569"
/db_xref="HGNC:HGNC:7492"
/db_xref="MIM:590065"
gene 4470..5511
/gene="ND2"
/gene_synonym="MTND2"
/nomenclature="Official Symbol: MT-ND2 | Name:
mitochondrially encoded NADH dehydrogenase 2 | Provided
by: HGNC:HGNC:7456"
/db_xref="GeneID:4536"
/db_xref="HGNC:HGNC:7456"
/db_xref="MIM:516001"
CDS 4470..5511
/gene="ND2"
/gene_synonym="MTND2"
/note="TAA stop codon is completed by the addition of 3' A
residues to the mRNA"
/codon_start=1
/transl_except=(pos:5511,aa:TERM)
/transl_table=2
/product="NADH dehydrogenase subunit 2"
/protein_id="YP_003024027.1"
/db_xref="GeneID:4536"
/db_xref="HGNC:HGNC:7456"
/db_xref="MIM:516001"
/translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVL
TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM
AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL
SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL
LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL
IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTT
LLLPISPFMLMIL"
STS 4481..5456
/gene="ND2"
/gene_synonym="MTND2"
/standard_name="PMC113853P1"
/db_xref="UniSTS:270258"
gene 5512..5579
/gene="TRNW"
/gene_synonym="MTTW"
/nomenclature="Official Symbol: MT-TW | Name:
mitochondrially encoded tRNA tryptophan | Provided by:
HGNC:HGNC:7501"
/db_xref="GeneID:4578"
/db_xref="HGNC:HGNC:7501"
/db_xref="MIM:590095"
tRNA 5512..5579
/gene="TRNW"
/gene_synonym="MTTW"
/product="tRNA-Trp"
/note="NAR: 1897"
/anticodon=(pos:5544..5546,aa:Trp,seq:tca)
/codon_recognized="UGA"
/db_xref="GeneID:4578"
/db_xref="HGNC:HGNC:7501"
/db_xref="MIM:590095"
gene complement(5587..5655)
/gene="TRNA"
/gene_synonym="MTTA"
/nomenclature="Official Symbol: MT-TA | Name:
mitochondrially encoded tRNA alanine | Provided by:
HGNC:HGNC:7475"
/db_xref="GeneID:4553"
/db_xref="HGNC:HGNC:7475"
/db_xref="MIM:590000"
tRNA complement(5587..5655)
/gene="TRNA"
/gene_synonym="MTTA"
/product="tRNA-Ala"
/note="NAR: 0097"
/anticodon=(pos:complement(5623..5625),aa:Ala,seq:tgc)
/codon_recognized="GCA"
/db_xref="GeneID:4553"
/db_xref="HGNC:HGNC:7475"
/db_xref="MIM:590000"
gene complement(5657..5729)
/gene="TRNN"
/gene_synonym="MTTN"
/nomenclature="Official Symbol: MT-TN | Name:
mitochondrially encoded tRNA asparagine | Provided by:
HGNC:HGNC:7493"
/db_xref="GeneID:4570"
/db_xref="HGNC:HGNC:7493"
/db_xref="MIM:590010"
tRNA complement(5657..5729)
/gene="TRNN"
/gene_synonym="MTTN"
/product="tRNA-Asn"
/note="NAR: 0297"
/anticodon=(pos:complement(5694..5696),aa:Asn,seq:gtt)
/codon_recognized="AAC"
/db_xref="GeneID:4570"
/db_xref="HGNC:HGNC:7493"
/db_xref="MIM:590010"
gene complement(5761..5826)
/gene="TRNC"
/gene_synonym="MTTC"
/nomenclature="Official Symbol: MT-TC | Name:
mitochondrially encoded tRNA cysteine | Provided by:
HGNC:HGNC:7477"
/db_xref="GeneID:4511"
/db_xref="HGNC:HGNC:7477"
/db_xref="MIM:590020"
tRNA complement(5761..5826)
/gene="TRNC"
/gene_synonym="MTTC"
/product="tRNA-Cys"
/note="NAR: 0497"
/anticodon=(pos:complement(5796..5798),aa:Cys,seq:gca)
/codon_recognized="UGC"
/db_xref="GeneID:4511"
/db_xref="HGNC:HGNC:7477"
/db_xref="MIM:590020"
gene complement(5826..5891)
/gene="TRNY"
/gene_synonym="MTTY"
/nomenclature="Official Symbol: MT-TY | Name:
mitochondrially encoded tRNA tyrosine | Provided by:
HGNC:HGNC:7502"
/db_xref="GeneID:4579"
/db_xref="HGNC:HGNC:7502"
/db_xref="MIM:590100"
tRNA complement(5826..5891)
/gene="TRNY"
/gene_synonym="MTTY"
/product="tRNA-Tyr"
/note="NAR: 1997"
/anticodon=(pos:complement(5860..5862),aa:Tyr,seq:gta)
/codon_recognized="UAC"
/db_xref="GeneID:4579"
/db_xref="HGNC:HGNC:7502"
/db_xref="MIM:590100"
gene 5904..7445
/gene="COX1"
/gene_synonym="COI; MTCO1"
/nomenclature="Official Symbol: MT-CO1 | Name:
mitochondrially encoded cytochrome c oxidase I | Provided
by: HGNC:HGNC:7419"
/db_xref="GeneID:4512"
/db_xref="HGNC:HGNC:7419"
/db_xref="MIM:516030"
CDS 5904..7445
/gene="COX1"
/gene_synonym="COI; MTCO1"
/note="cytochrome c oxidase I"
/codon_start=1
/transl_table=2
/product="cytochrome c oxidase subunit I"
/protein_id="YP_003024028.1"
/db_xref="GeneID:4512"
/db_xref="HGNC:HGNC:7419"
/db_xref="MIM:516030"
/translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP
GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF
WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG
AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT
FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA
MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW
SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG
FIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW
NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEP
VYMKS"
STS 6318..6918
/gene="COX1"
/gene_synonym="COI; MTCO1"
/standard_name="PMC55343P2"
/db_xref="UniSTS:273325"
STS 7125..7672
/standard_name="PMC20756P3"
/db_xref="UniSTS:271963"
STS 7166..7361
/gene="COX1"
/gene_synonym="COI; MTCO1"
/standard_name="D17S813E"
/db_xref="UniSTS:92461"
STS 7358..7937
/standard_name="PMC55343P3"
/db_xref="UniSTS:273326"
STS 7386..7513
/standard_name="RH98513"
/db_xref="UniSTS:83580"
gene complement(7446..7514)
/gene="TRNS1"
/gene_synonym="MTTS1"
/nomenclature="Official Symbol: MT-TS1 | Name:
mitochondrially encoded tRNA serine 1 (UCN)"
/db_xref="GeneID:4574"
/db_xref="HGNC:HGNC:7497"
/db_xref="MIM:590080"
tRNA complement(7446..7514)
/gene="TRNS1"
/gene_synonym="MTTS1"
/product="tRNA-Ser"
/note="NAR: 1697"
/anticodon=(pos:complement(7482..7484),aa:Ser,seq:tga)
/codon_recognized="UCN"
/db_xref="GeneID:4574"
/db_xref="HGNC:HGNC:7497"
/db_xref="MIM:590080"
STS 7483..8383
/standard_name="PMC20756P2"
/db_xref="UniSTS:271962"
STS 7483..8364
/standard_name="PMC109173P1"
/db_xref="UniSTS:270154"
STS 7483..7570
/standard_name="PMC20756P1"
/db_xref="UniSTS:271961"
gene 7518..7585
/gene="TRND"
/gene_synonym="MTTD"
/nomenclature="Official Symbol: MT-TD | Name:
mitochondrially encoded tRNA aspartic acid | Provided by:
HGNC:HGNC:7478"
/db_xref="GeneID:4555"
/db_xref="HGNC:HGNC:7478"
/db_xref="MIM:590015"
tRNA 7518..7585
/gene="TRND"
/gene_synonym="MTTD"
/product="tRNA-Asp"
/note="NAR: 0397"
/anticodon=(pos:7548..7550,aa:Asp,seq:gtc)
/codon_recognized="GAC"
/db_xref="GeneID:4555"
/db_xref="HGNC:HGNC:7478"
/db_xref="MIM:590015"
STS 7561..7983
/standard_name="PMC196577P3"
/db_xref="UniSTS:271816"
gene 7586..8269
/gene="COX2"
/gene_synonym="COII; MTCO2"
/nomenclature="Official Symbol: MT-CO2 | Name:
mitochondrially encoded cytochrome c oxidase II | Provided
by: HGNC:HGNC:7421"
/db_xref="GeneID:4513"
/db_xref="HGNC:HGNC:7421"
/db_xref="MIM:516040"
CDS 7586..8269
/gene="COX2"
/gene_synonym="COII; MTCO2"
/note="cytochrome c oxidase II"
/codon_start=1
/transl_table=2
/product="cytochrome c oxidase subunit II"
/protein_id="YP_003024029.1"
/db_xref="GeneID:4513"
/db_xref="HGNC:HGNC:7421"
/db_xref="MIM:516040"
/translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL
TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH
QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVL
HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI
FEMGPVFTL"
STS 7690..7773
/gene="COX2"
/gene_synonym="COII; MTCO2"
/standard_name="D1S2077E"
/db_xref="UniSTS:151716"
STS 8164..8291
/standard_name="SHGC-57364"
/db_xref="UniSTS:67674"
STS 8280..8882
/standard_name="PMC55343P5"
/db_xref="UniSTS:273328"
STS 8280..8366
/standard_name="PMC55343P4"
/db_xref="UniSTS:273327"
gene 8295..8364
/gene="TRNK"
/gene_synonym="MTTK"
/nomenclature="Official Symbol: MT-TK | Name:
mitochondrially encoded tRNA lysine | Provided by:
HGNC:HGNC:7489"
/db_xref="GeneID:4566"
/db_xref="HGNC:HGNC:7489"
/db_xref="MIM:590060"
tRNA 8295..8364
/gene="TRNK"
/gene_synonym="MTTK"
/product="tRNA-Lys"
/note="NAR: 1197"
/anticodon=(pos:8323..8325,aa:Lys,seq:ttt)
/codon_recognized="AAA"
/db_xref="GeneID:4566"
/db_xref="HGNC:HGNC:7489"
/db_xref="MIM:590060"
gene 8366..8572
/gene="ATP8"
/gene_synonym="ATPase8; MTATP8"
/nomenclature="Official Symbol: MT-ATP8 | Name:
mitochondrially encoded ATP synthase 8 | Provided by:
HGNC:HGNC:7415"
/db_xref="GeneID:4509"
/db_xref="HGNC:HGNC:7415"
/db_xref="MIM:516070"
CDS 8366..8572
/gene="ATP8"
/gene_synonym="ATPase8; MTATP8"
/note="ATP synthase 8; ATPase subunit 8"
/codon_start=1
/transl_table=2
/product="ATP synthase F0 subunit 8"
/protein_id="YP_003024030.1"
/db_xref="GeneID:4509"
/db_xref="HGNC:HGNC:7415"
/db_xref="MIM:516070"
/translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKM
KNYNKPWEPKWTKICSLHSLPPQS"
gene 8527..9207
/gene="ATP6"
/gene_synonym="ATPase6; MTATP6"
/nomenclature="Official Symbol: MT-ATP6 | Name:
mitochondrially encoded ATP synthase 6 | Provided by:
HGNC:HGNC:7414"
/db_xref="GeneID:4508"
/db_xref="HGNC:HGNC:7414"
/db_xref="MIM:516060"
CDS 8527..9207
/gene="ATP6"
/gene_synonym="ATPase6; MTATP6"
/note="ATP synthase 6; ATPase subunit 6"
/codon_start=1
/transl_table=2
/product="ATP synthase F0 subunit 6"
/protein_id="YP_003024031.1"
/db_xref="GeneID:4508"
/db_xref="HGNC:HGNC:7414"
/db_xref="MIM:516060"
/translation="MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT
TQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNL
AMAIPLWAGTVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRL
TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV
SLYLHDNT"
STS 8779..9416
/standard_name="PMC55343P7"
/db_xref="UniSTS:273330"
STS 8779..8882
/gene="ATP6"
/gene_synonym="ATPase6; MTATP6"
/standard_name="PMC55343P6"
/db_xref="UniSTS:273329"
gene 9207..9990
/gene="COX3"
/gene_synonym="COIII; MTCO3"
/nomenclature="Official Symbol: MT-CO3 | Name:
mitochondrially encoded cytochrome c oxidase III |
Provided by: HGNC:HGNC:7422"
/db_xref="GeneID:4514"
/db_xref="HGNC:HGNC:7422"
/db_xref="MIM:516050"
CDS 9207..9990
/gene="COX3"
/gene_synonym="COIII; MTCO3"
/note="cytochrome c oxidase III; TAA stop codon is
completed by the addition of 3' A residues to the mRNA"
/codon_start=1
/transl_except=(pos:9990,aa:TERM)
/transl_table=2
/product="cytochrome c oxidase subunit III"
/protein_id="YP_003024032.1"
/db_xref="GeneID:4514"
/db_xref="HGNC:HGNC:7422"
/db_xref="MIM:516050"
/translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM
LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFY
HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMI
QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC
FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS"
STS 9342..9416
/gene="COX3"
/gene_synonym="COIII; MTCO3"
/standard_name="PMC55343P8"
/db_xref="UniSTS:273331"
gene 9991..10058
/gene="TRNG"
/gene_synonym="MTTG"
/nomenclature="Official Symbol: MT-TG | Name:
mitochondrially encoded tRNA glycine | Provided by:
HGNC:HGNC:7486"
/db_xref="GeneID:4563"
/db_xref="HGNC:HGNC:7486"
/db_xref="MIM:590035"
tRNA 9991..10058
/gene="TRNG"
/gene_synonym="MTTG"
/product="tRNA-Gly"
/note="NAR: 0797"
/anticodon=(pos:10021..10023,aa:Gly,seq:tcc)
/codon_recognized="GGA"
/db_xref="GeneID:4563"
/db_xref="HGNC:HGNC:7486"
/db_xref="MIM:590035"
gene 10059..10404
/gene="ND3"
/gene_synonym="MTND3"
/nomenclature="Official Symbol: MT-ND3 | Name:
mitochondrially encoded NADH dehydrogenase 3 | Provided
by: HGNC:HGNC:7458"
/db_xref="GeneID:4537"
/db_xref="HGNC:HGNC:7458"
/db_xref="MIM:516002"
CDS 10059..10404
/gene="ND3"
/gene_synonym="MTND3"
/note="NADH dehydrogenase, subunit 3 (complex I); TAA stop
codon is completed by the addition of 3' A residues to the
mRNA"
/codon_start=1
/transl_except=(pos:10404,aa:TERM)
/transl_table=2
/product="NADH dehydrogenase subunit 3"
/protein_id="YP_003024033.1"
/db_xref="GeneID:4537"
/db_xref="HGNC:HGNC:7458"
/db_xref="MIM:516002"
/translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM
SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL
AYEWLQKGLDWTE"
gene 10405..10469
/gene="TRNR"
/gene_synonym="MTTR"
/nomenclature="Official Symbol: MT-TR | Name:
mitochondrially encoded tRNA arginine | Provided by:
HGNC:HGNC:7496"
/db_xref="GeneID:4573"
/db_xref="HGNC:HGNC:7496"
/db_xref="MIM:590005"
tRNA 10405..10469
/gene="TRNR"
/gene_synonym="MTTR"
/product="tRNA-Arg"
/note="NAR: 0197"
/anticodon=(pos:10435..10437,aa:Arg,seq:tcg)
/codon_recognized="CGA"
/db_xref="GeneID:4573"
/db_xref="HGNC:HGNC:7496"
/db_xref="MIM:590005"
gene 10470..10766
/gene="ND4L"
/gene_synonym="MTND4L"
/nomenclature="Official Symbol: MT-ND4L | Name:
mitochondrially encoded NADH 4L dehydrogenase | Provided
by: HGNC:HGNC:7460"
/db_xref="GeneID:4539"
/db_xref="HGNC:HGNC:7460"
/db_xref="MIM:516004"
CDS 10470..10766
/gene="ND4L"
/gene_synonym="MTND4L"
/note="NADH dehydrogenase, subunit 4L (complex I)"
/codon_start=1
/transl_table=2
/product="NADH dehydrogenase subunit 4L"
/protein_id="YP_003024034.1"
/db_xref="GeneID:4539"
/db_xref="HGNC:HGNC:7460"
/db_xref="MIM:516004"
/translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA
TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC"
gene 10760..12137
/gene="ND4"
/gene_synonym="MTND4"
/nomenclature="Official Symbol: MT-ND4 | Name:
mitochondrially encoded NADH dehydrogenase 4 | Provided
by: HGNC:HGNC:7459"
/db_xref="GeneID:4538"
/db_xref="HGNC:HGNC:7459"
/db_xref="MIM:516003"
CDS 10760..12137
/gene="ND4"
/gene_synonym="MTND4"
/note="NADH dehydrogenase, subunit 4 (complex I); TAA stop
codon is completed by the addition of 3' A residues to the
mRNA"
/codon_start=1
/transl_except=(pos:12137,aa:TERM)
/transl_table=2
/product="NADH dehydrogenase subunit 4"
/protein_id="YP_003024035.1"
/db_xref="GeneID:4538"
/db_xref="HGNC:HGNC:7459"
/db_xref="MIM:516003"
/translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ
INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL
QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL
LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK
AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC
LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY
ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT
LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN
PDIITGFSS"
gene 12138..12206
/gene="TRNH"
/gene_synonym="MTTH"
/nomenclature="Official Symbol: MT-TH | Name:
mitochondrially encoded tRNA histidine | Provided by:
HGNC:HGNC:7487"
/db_xref="GeneID:4564"
/db_xref="HGNC:HGNC:7487"
/db_xref="MIM:590040"
tRNA 12138..12206
/gene="TRNH"
/gene_synonym="MTTH"
/product="tRNA-His"
/note="NAR: 0897"
/anticodon=(pos:12168..12170,aa:His,seq:gtg)
/codon_recognized="CAC"
/db_xref="GeneID:4564"
/db_xref="HGNC:HGNC:7487"
/db_xref="MIM:590040"
gene 12207..12265
/gene="TRNS2"
/gene_synonym="MTTS2"
/nomenclature="Official Symbol: MT-TS2 | Name:
mitochondrially encoded tRNA serine 2 (AGU/C) | Provided
by: HGNC:HGNC:7498"
/db_xref="GeneID:4575"
/db_xref="HGNC:HGNC:7498"
/db_xref="MIM:590085"
tRNA 12207..12265
/gene="TRNS2"
/gene_synonym="MTTS2"
/product="tRNA-Ser"
/note="NAR: 1656"
/anticodon=(pos:12226..12228,aa:Ser,seq:gct)
/codon_recognized="AGY"
/db_xref="GeneID:4575"
/db_xref="HGNC:HGNC:7498"
/db_xref="MIM:590085"
gene 12266..12336
/gene="TRNL2"
/gene_synonym="MTTL2"
/nomenclature="Official Symbol: MT-TL2 | Name:
mitochondrially encoded tRNA leucine 2 (CUN) | Provided
by: HGNC:HGNC:7491"
/db_xref="GeneID:4568"
/db_xref="HGNC:HGNC:7491"
/db_xref="MIM:590055"
tRNA 12266..12336
/gene="TRNL2"
/gene_synonym="MTTL2"
/product="tRNA-Leu"
/note="NAR: 1097"
/anticodon=(pos:12298..12300,aa:Leu,seq:tag)
/codon_recognized="CUN"
/db_xref="GeneID:4568"
/db_xref="HGNC:HGNC:7491"
/db_xref="MIM:590055"
gene 12337..14148
/gene="ND5"
/gene_synonym="MTND5"
/nomenclature="Official Symbol: MT-ND5 | Name:
mitochondrially encoded NADH dehydrogenase 5 | Provided
by: HGNC:HGNC:7461"
/db_xref="GeneID:4540"
/db_xref="HGNC:HGNC:7461"
/db_xref="MIM:516005"
CDS 12337..14148
/gene="ND5"
/gene_synonym="MTND5"
/note="NADH dehydrogenase, subunit 5 (complex I)"
/codon_start=1
/transl_table=2
/product="NADH dehydrogenase subunit 5"
/protein_id="YP_003024036.1"
/db_xref="GeneID:4540"
/db_xref="HGNC:HGNC:7461"
/db_xref="MIM:516005"
/translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF
IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME
FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA
RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL
AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTL
TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAF
FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK
DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL
LNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLT
NKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTI
SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT"
STS 13068..13143
/gene="ND5"
/gene_synonym="MTND5"
/standard_name="PMC55343P9"
/db_xref="UniSTS:273332"
STS 13593..14206
/standard_name="PMC55343P10"
/db_xref="UniSTS:273323"
STS 14104..14206
/standard_name="PMC55343P12"
/db_xref="UniSTS:273324"
gene complement(14149..14673)
/gene="ND6"
/gene_synonym="MTND6"
/nomenclature="Official Symbol: MT-ND6 | Name:
mitochondrially encoded NADH dehydrogenase 6 | Provided
by: HGNC:HGNC:7462"
/db_xref="GeneID:4541"
/db_xref="HGNC:HGNC:7462"
/db_xref="MIM:516006"
CDS complement(14149..14673)
/gene="ND6"
/gene_synonym="MTND6"
/note="NADH dehydrogenase, subunit 6 (complex I)"
/codon_start=1
/transl_table=2
/product="NADH dehydrogenase subunit 6"
/protein_id="YP_003024037.1"
/db_xref="GeneID:4541"
/db_xref="HGNC:HGNC:7462"
/db_xref="MIM:516006"
/translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL
NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL
VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL
FVGVYIVIEIARGN"
gene complement(14674..14742)
/gene="TRNE"
/gene_synonym="MTTE"
/nomenclature="Official Symbol: MT-TE | Name:
mitochondrially encoded tRNA glutamic acid | Provided by:
HGNC:HGNC:7479"
/db_xref="GeneID:4556"
/db_xref="HGNC:HGNC:7479"
/db_xref="MIM:590025"
tRNA complement(14674..14742)
/gene="TRNE"
/gene_synonym="MTTE"
/product="tRNA-Glu"
/note="NAR: 0697"
/anticodon=(pos:complement(14710..14712),aa:Glu,seq:ttc)
/codon_recognized="GAA"
/db_xref="GeneID:4556"
/db_xref="HGNC:HGNC:7479"
/db_xref="MIM:590025"
gene 14747..15887
/gene="CYTB"
/gene_synonym="MTCYB"
/nomenclature="Official Symbol: MT-CYB | Name:
mitochondrially encoded cytochrome b | Provided by:
HGNC:HGNC:7427"
/db_xref="GeneID:4519"
/db_xref="HGNC:HGNC:7427"
/db_xref="MIM:516020"
CDS 14747..15887
/gene="CYTB"
/gene_synonym="MTCYB"
/note="TAA stop codon is completed by the addition of 3' A
residues to the mRNA"
/codon_start=1
/transl_except=(pos:15887,aa:TERM)
/transl_table=2
/product="cytochrome b"
/protein_id="YP_003024038.1"
/db_xref="GeneID:4519"
/db_xref="HGNC:HGNC:7427"
/db_xref="MIM:516020"
/translation="MTPMRKTNPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ
ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL
YYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL
VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKI
TFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF
AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI
LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA"
STS 15191..15307
/gene="CYTB"
/gene_synonym="MTCYB"
/standard_name="GDB:451664"
/db_xref="UniSTS:157340"
STS 15698..15777
/gene="CYTB"
/gene_synonym="MTCYB"
/standard_name="D1S2076E"
/db_xref="UniSTS:151706"
gene 15888..15953
/gene="TRNT"
/gene_synonym="MTTT"
/nomenclature="Official Symbol: MT-TT | Name:
mitochondrially encoded tRNA threonine | Provided by:
HGNC:HGNC:7499"
/db_xref="GeneID:4576"
/db_xref="HGNC:HGNC:7499"
/db_xref="MIM:590090"
tRNA 15888..15953
/gene="TRNT"
/gene_synonym="MTTT"
/product="tRNA-Thr"
/note="NAR: 1797"
/anticodon=(pos:15919..15921,aa:Thr,seq:tgt)
/codon_recognized="ACA"
/db_xref="GeneID:4576"
/db_xref="HGNC:HGNC:7499"
/db_xref="MIM:590090"
gene complement(15956..16023)
/gene="TRNP"
/gene_synonym="MTTP"
/nomenclature="Official Symbol: MT-TP | Name:
mitochondrially encoded tRNA proline | Provided by:
HGNC:HGNC:7494"
/db_xref="GeneID:4571"
/db_xref="HGNC:HGNC:7494"
/db_xref="MIM:590075"
tRNA complement(15956..16023)
/gene="TRNP"