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R scripts & functions for SNP data analysis of genotyping data from Affymetrix Axiom arrays

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leaf_print

In early development phase.

Developers: Tom Poorten, Randi Famula, Mitchell Feldmann

Functions to build:

  • read in data - DONE
  • filter SNPs - keep only polymorphic well-behaving (biallelic) SNPs
  • make QAQC plots - sample-wise missing data distribution, ...?
  • filter samples - by quality or vector of arbitrary sample IDs
  • calc sample heterozygosity
  • convert to GDS format for SNPRelate R package
  • assess replicate samples and keep one sample per replicate set
    • for expected reps - keep sample with best call rate
    • for unexpected reps - keep sample that is pedigree-confirmed if possible
  • pop structure viz - PCA
    • flag unexpected PC values based on reported taxonomy
  • pedigree analysis (IBD-based inference of PO relationships)

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R scripts & functions for SNP data analysis of genotyping data from Affymetrix Axiom arrays

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